2P234 Functional interaction between sarcoplasmic reticulum Ca^<2+>-ATPases
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On the inhibition mechanism of sarcoplasmic or endoplasmic reticulum Ca2+-ATPases by cyclopiazonic acid.
Ca2+-ATPase inhibition by stoichiometric and substoichiometric concentrations of cyclopiazonic acid was studied in sarcoplasmic reticulum preparations from rabbit fast-twitch muscle. The apparent affinity of the nonphosphorylated enzyme for ATP showed a Kd of approximately 3 microM in the absence of cyclopiazonic acid and approximately 28 microM in the presence of the drug. Fractional saturatio...
متن کاملDistances between the functional sites of the (Ca2+ + Mg2+)-ATPase of sarcoplasmic reticulum.
Luminescence energy transfer measurements have been used to determine the distances between the two high affinity Ca2+ binding-transport sites of the (Ca2+ + Mg2+)-ATPase of skeletal muscle sarcoplasmic reticulum. The lanthanide Tb3+ situated at one high affinity Ca2+ site was used as the transfer donor, and acceptors at the other Ca2+ site were the lanthanides Nd3+, Pr3+, Ho3+, or Er3+. Terbiu...
متن کاملModulation of (Ca2+ +Mg2+)-ATPases and Ca2+ fluxes through the plasma membrane of synaptosomes and sarcoplasmic reticulum by local anaesthetics.
14. Silvius. J . K. & Gagne, J. ( 19x4) Hiochmiistry 23, 324 1-3247 15. Hope, M. J. & Cullis, P. R. (1980) Biochem. Biophys. Res. Cornmiin. 92,846-852 16. Portis, A,, Newton, C., Pangborn, W. & Papahadjopoulos, D. ( 1979) Biochemistry 18, 780-790 17. Jacobson, K. & Papahadjopoulos, D. ( 1975) Biochemisfy 14, 152-lhl 18. Ellens, H.. Siegel, D., Alford. I)., Yeagle, P. L.. Boni, L., Lis. L. J.. Q...
متن کاملCa2’-ATPase Membrane Crystals in Sarcoplasmic Reticulum
Vanadate induces the formation of two-dimensional crystalline arrays of Ca2+-ATPase molecules in sarcoplasmic reticulum. The Ca2+-ATPase membrane crystals are evenly distributed among the terminal cisternae and longitudinal tubules of sarcoplasmic reticulum, but very few crystals were observed in the T tubules. Tryptic cleavage of the Ca2+ transport ATPase into two major fragments (A and B) did...
متن کاملExcessive sarcoplasmic/endoplasmic reticulum Ca2+-ATPase expression causes increased sarcoplasmic reticulum Ca2+ uptake but decreases myocyte shortening.
BACKGROUND Increasing sarcoplasmic/endoplasmic reticulum (SR) Ca2+-ATPase (SERCA) uptake activity is a promising therapeutic approach for heart failure. We investigated the effects of different levels of SERCA1a expression on contractility and Ca2+ cycling. We tested whether increased SERCA1a expression levels enhance myocyte contractility in a gene-dose-dependent manner. METHODS AND RESULTS ...
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ژورنال
عنوان ژورنال: Seibutsu Butsuri
سال: 2004
ISSN: 0582-4052,1347-4219
DOI: 10.2142/biophys.44.s168_2